Based on histopathology and molecular genetic alterations, ovarian carcinomas are divided into five main types (high-grade serous (70%), endometrioid (10%), clear cell (10%), mucinous (3%), and low-grade serous carcinomas (<5%)) that account for over 95% of cases. These types are essentially distinct diseases, as indicated by differences in epidemiological and genetic risk factors, precursor lesions, patterns of spread, and molecular events during oncogenesis, response to chemotherapy, and prognosis. For a successful specific treatment, reproducible histopathological diagnosis of the tumor cell type is critical.
(Dall' Abstract di Prat J. Ovarian carcinomas: five distinct diseases with different origins, genetic alterations, and clinicopathological features).
Bibliografia:
Representative examples of the five main types of ovarian carcinoma, which together account for 98% of cases: a High-grade serous carcinoma; b Low-grade serous carcinoma; c Mucinous carcinoma; d Endometrioid carcinoma; and e Clear cell carcinoma (da Prat J, Virchows Arch. Mar. 2012).
