PATHfinder: Colon Cancer

martedì 25 marzo 2014

Journal Club #2 - Tumor budding as prognostic marker in colorectal cancer

Tumor budding (defined as single neoplastic cells or clusters up to five cells at the invasive front of CRC) may represent a new prognostic marker in colorectal cancer. In particular, it could be useful to indentify those pT3N0M0 "high risk" patients who may benefit of additional therapeutic regimen.

Interestingly, tumor budding can be assessed also in pre-operative biopsy and in cancers other than CRCs.

Overview of the histomorphological and molecular features of the tumour centre, invasive front and tumour buds in CRC. Reproduced from Zlobec and Lugli, 2010.

Bibliography.

Wang LM, Kevans D, Mulcahy H, O'Sullivan J, Fennelly D, Hyland J, O'Donoghue D, Sheahan K. Tumor budding is a strong and reproducible prognostic marker in T3N0 colorectal cancer. Am J Surg Pathol. 2009 Jan;33(1):134-41.

Lugli A, Karamitopoulou E, Zlobec I. Tumour budding: a promising parameter in colorectal cancer. Br J Cancer. 2012 May 22;106(11):1713-7. doi: 10.1038/bjc.2012.127. Epub 2012 Apr 24. Review.

Rogers AC, Gibbons D, Hanly AM, Hyland JM, O'Connell PR, Winter DC, Sheahan K. Prognostic significance of tumor budding in rectal cancer biopsies before neoadjuvant therapy. Mod Pathol. 2014 Jan;27(1):156-62.

Giger OT, Comtesse SC, Lugli A, Zlobec I, Kurrer MO. Intra-tumoral budding in preoperative biopsy specimens predicts lymph node and distant metastasis in patients with colorectal cancer. Mod Pathol. 2012 Jul;25(7):1048-53.

Sarioglu S, Acara C, Akman FC, Dag N, Ecevit C, Ikiz AO, Cetinayak OH, Ada E; for Dokuz Eylül Head and Neck Tumour Group (DEHNTG). Tumor budding as a prognostic marker in laryngeal carcinoma. Pathol Res Pract. 2010 Feb 15;206(2):88-92.

Liang F, Cao W, Wang Y, Li L, Zhang G, Wang Z. The prognostic value of tumor budding in invasive breast cancer. Pathol Res Pract. 2013 May;209(5):269-75.

Caro PATHfinder,

se può essere utile, voglio passarti un piccolo contributo sul cancro del colon.

Ti allego alcuni articoli di Quirke molto didattici che spiegano qual è il metodo e l'obiettivo del patologo nella diagnosi dei tumori del retto. Due articoli spiegano molto chiaramente tutte le possibili lesioni che vanno diagnosticate; un articolo guida nel report macroscopico e microscopico, un altro spiega bene qual è il significato del margine radiale nelle resezioni del retto e come va valutato.

Penso possa essere molto d'aiuto per tutti.

Ciao

Severo Campione, MD.