The International Society of Urological Pathology (ISUP) is the international professional organization dedicated to the subspecialty of urological pathology. [...] In 2011 the Society undertook to review all aspects of the pathology of adult renal malignancy through an international consensus conference [...]. The detailed decisions relating to the consensus conference are presented in 4 reports, included this issue of the journal.
Delahunt B, Egevad L, Montironi R, Srigley JR. International Society of Urological Pathology (ISUP) Consensus Conference on Renal Neoplasia: Rationale and Organization. Am J Surg Pathol. 2013 Oct;37(10):1463-8.
Srigley JR, et al The ISUP Renal Tumor Panel. The International Society of Urological Pathology (ISUP) Vancouver Classification of Renal Neoplasia. Am J Surg Pathol. 2013 Oct;37(10):1469-1489.
A 69-year-old man, with a history of renal cancer 11 years ago, presented with a 1 cm right lung nodule, which was investigated with fine-needle aspiration under computed tomography guidance. A, Cell block preparation shows tumor cells with pink cytoplasm. B, Higher magnification of tumor cells with pink cytoplasm and nuclei that are vesicular and hyperchromatic. C, Immunohistochemical analysis with RCC marker shows strong cytoplasmic reactivity. D, Pax 2 immunohistochemistry reveals strong nuclear staining, confirming a metastasis to the lung from a primary renal tumor.
Pax 2 and/or Pax 8 were considered to be the most useful markers in the diagnosis of a renal primary.
(from Tan PH, et al, Diagnostic and Prognostic Biomarkers)
P.S. Post n. 100!
P.S. Post n. 100!
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